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Who was excluded from these trials, and who that leaves out

Started 12 October 2025 · 13 replies · 119 hearts · read 1.6k times

PamSouthport, UK · 12 October 2025
9 months ago

A question rather than an update: Who was excluded from these trials, and who that leaves out

Putting this here because I do not want to be sold anything, I want to know what is actually established.

I have a document in front of me and I can read every line of it and I still cannot tell what it proves.

Everything discussed in this circle is research-use-only material and is not approved for use in a person, and my question is about the evidence rather than about use.

If anybody has the primary source, I would be very grateful for it — I have been going round in circles.

40

EphraimBrooklyn, NY
#1

The paper we read last month had a population nothing like most of this circle, which does not make it useless and does limit what it tells us.

6me too 6

SunilFacilitatorBirmingham, UK
#2

Two things, both boring. None of us can tell you what is safe for you. And an evidence base being thin is information rather than a gap to fill with reasoning.

17

SaoirseKilkenny, IE
#3

To the opening post rather than to the thread: Pam, this is my version of it.

Something I got wrong early was reading a single paper as an answer. It is one piece of evidence and it usually raises three questions.

8

StellanMalmö, SE
#4

I would say do read the supplementary material occasionally. Twice now the thing I wanted to know was only in there.

10

TiborBratislava, SK
#5

What helped was somebody explaining confidence intervals to me properly, once, in plain terms, and I have read differently ever since.

6

GilTel Aviv, IL
#6

Reading this properly rather than skimming, which is all I have to offer today.

8

PádraigGalway, IE
#7

I found the funding declarations worth reading, not as an accusation, but because they tell you what question somebody was paying to have answered.

4

PriyaReading, UK
#8

Building on what Tibor wrote rather than answering the original question.

The withdrawal numbers in a trial usually tell you more about tolerability than the tolerability section does.

11me too 7

GwendaEbbw Vale, UK
#9

My honest position is that the evidence base for the main compounds is genuinely substantial and the evidence for a great deal else is not.

12

OskarWarsaw, PL
#10

What surprised me was how readable most of these are once you stop being intimidated by the first page.

10me too 4

NilsUppsala, SE
#11

Somebody here asked what would change our minds, at the start of a session, and it improved the discussion enormously.

9

SunilFacilitatorBirmingham, UK
#12

Facilitator note: if the last few replies have touched something for you, there is no need to say so here. Our support resources page lists what to look for, quietly and without any drama.

12

BettinaGraz, AT
#13

I found the discussion sections the least reliable part of most papers and the results tables the most.

6me too 3