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SUMMIT and heart failure with preserved ejection fraction

Started 1 August 2025 · 19 replies · 177 hearts · read 3.6k times

SaoirseKilkenny, IE · 1 August 2025
12 months ago

Something I have been sitting with: SUMMIT and heart failure with preserved ejection fraction Not looking for advice so much as other people's experience.

Putting this here because I do not want to be sold anything, I want to know what is actually established.

I am asking because two people I trust have told me opposite things and both of them cited the same study.

Everything discussed in this circle is research-use-only material and is not approved for use in a person, and my question is about the evidence rather than about use.

If anybody has the primary source, I would be very grateful for it — I have been going round in circles.

59

NadjaBelgrade, RS
#1

I found the funding declarations worth reading, not as an accusation, but because they tell you what question somebody was paying to have answered.

6

SunilFacilitatorBirmingham, UK
#2

Stepping in to say that the lot-number check is the only verification that is entirely yours, and it is worth repeating on every thread here.

21me too 5

OskarWarsaw, PL
#3

My favourite session here was the one where we read a paper and concluded it did not support the thing everybody had been citing it for.

8

PrunellaBury St Edmunds, UK
#4

Something worth knowing: the follow-up periods in most of what we read are short relative to how long people actually take these things.

10

AmmiKarachi, PK
#5

Thank you. Genuinely.

5me too 1

TiborBratislava, SK
#6

Oskar, thank you for that. It gives me somewhere to start from.

What I would say is that an honest "we do not know yet" is worth more than a confident answer, and the papers say it more often than the coverage does.

7

PamSouthport, UK
#7

Coming back to what Prunella wrote further up, because it is the bit I keep thinking about.

I had to learn that an effect being statistically significant and it mattering to a person are two entirely separate questions.

7

StellanMalmö, SE
#8

Something practical: I read the methods before the conclusions now, which somebody here suggested and which changed how much I trust what I read.

9

EphraimBrooklyn, NY
#9

The thing I look at first now is who was actually in the study, because that is usually where the answer to my question lives.

9

PádraigGalway, IE
#10

What I found is that the abstract and the results section quite often tell slightly different stories, and the difference is the interesting part.

6

PriyaReading, UK
#11

My honest position is that the evidence base for the main compounds is genuinely substantial and the evidence for a great deal else is not.

12

NissaHaifa, IL
#12

Picking up Ephraim’s point rather than starting a new one.

What helped was somebody explaining confidence intervals to me properly, once, in plain terms, and I have read differently ever since.

10

BeaDublin, IE
#13

The withdrawal numbers in a trial usually tell you more about tolerability than the tolerability section does.

8me too 5

NkemPort Harcourt, NG
#14

Something I got wrong early was reading a single paper as an answer. It is one piece of evidence and it usually raises three questions.

6

JuniperMachynlleth, UK
#15

Here, reading, and glad you posted.

11

TildaCambridge, UK
#16

I would say do read the supplementary material occasionally. Twice now the thing I wanted to know was only in there.

9

GwendaEbbw Vale, UK
#17

The paper we read last month had a population nothing like most of this circle, which does not make it useless and does limit what it tells us.

9

SunilFacilitatorBirmingham, UK
#18

Speaking as a facilitator: we do not name individuals in this circle and we do not accuse anybody of anything. We describe what a document does and does not show.

13me too 1

DoraUtrecht, NL
#19

The trial that gets quoted most in general coverage is not the one that answers most of the questions people here actually have.

11