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Peptides beyond GLP-1

What a phase 1 result can and cannot tell you

Started 5 January 2026 · 14 replies · 102 hearts · read 923 times

FabianBasel, CH · 5 January 2026
6 months ago

What a phase 1 result can and cannot tell you Writing it down partly to work out what I actually think.

Evidence question. I would rather have an honest "we do not know" than a confident answer.

I would like to know what the best single piece of human evidence is, because I suspect the honest answer is thinner than the discussion suggests.

I have a practical question that turns entirely on a technical detail, and I have not been able to get a straight answer to the technical detail.

To put the figure in the title beside the rest of it: 1. That is the whole of the arithmetic and none of it is an estimate.

I will summarise whatever the thread concludes and add it to my notes, in case it is useful to somebody later.

34

PolaGdańsk, PL
#1

What I keep coming back to is that a compound having a plausible mechanism and a compound having human outcome data are very different situations.

7

SunilFacilitatorBirmingham, UK
#2

Noticing a habit rather than anybody in particular: a small study cited three times is still one study, and a page can look well sourced when it is quoting itself.

16

IdrisCardiff, UK
#3

Gently disagreeing with Sunil, or rather adding the other half of it.

Nothing in this circle is medical advice and none of us is in a position to tell you what is safe for you.

4

NevGrimsby, UK
#4

Nothing here is a recommendation. This circle exists to be honest about where the evidence runs out, not to fill the gap with confidence.

6

BunnyWeston-super-Mare, UK
#5

Idris — yes, and the bit that took me longest to accept was the next part.

Coming back to say I read for a year and decided against, and that this circle was where I got the information to decide with.

8

FlossieShrewsbury, UK
#6

This is where the evidence thins out and I would rather this circle said so plainly than pretended otherwise.

9me too 4

MorayElgin, UK
#7

Everything discussed here is research-use-only material. That is not a formality: it was never manufactured, released or documented for use in a person.

4

WellsChester, UK
#8

Reading Flossie, I recognised more of that than I expected to.

The honest answer to most questions in this circle is that nobody has run the study that would answer them.

6

MableBolton, UK
#9

I would say be very careful with anything where the entire published record is animal work. That is a starting point, not a finding.

3

TobinCork, IE
#10

Saying it out loud helps other people say it too. Thank you.

9

TacitaRome, IT
#11

My reading of the published record on most of these is that it is early, small and mostly not in people.

5

TamarPlymouth, UK
#12

Something I got wrong was assuming that because something is discussed everywhere it must have a body of evidence behind it.

7

SunilFacilitatorBirmingham, UK
#13

Speaking plainly: nothing here is medical advice and nothing here makes research-use-only material appropriate for use in a person.

13

FabianBasel, CH
#14

Grateful you posted rather than kept it to yourself.

5me too 2